GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs1577917 | 1 | rs1911553 | chr6:86630892 | SNHG5 | chr6:86386726-86388451:- | -0.51 | -9.04 | 7.68E-18 | Response to antipsychotic treatment |
| BLCA | cis | rs10935120 | 1 | rs1917130 | chr3:134313773 | ANAPC13 | chr3:134196547-134204865:- | -0.48 | -7.64 | 1.79E-13 | Height |
| BLCA | cis | rs6547741 | 1 | rs1919125 | chr2:27801403 | C2orf16 | chr2:27799389-27805588:+ | 0.23 | 3.94 | 9.54E-5 | Oral cavity cancer |
| BLCA | cis | rs6547741 | 1 | rs1919126 | chr2:27801418 | C2orf16 | chr2:27799389-27805588:+ | 0.23 | 3.94 | 9.54E-5 | Oral cavity cancer |
| BLCA | cis | rs11976180 | 1 | rs1919948 | chr7:143762843 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.06 | 3.3E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs1919949 | chr7:143767723 | ARHGEF35 | chr7:143883677-143892736:- | -0.31 | -5.46 | 8.47E-8 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs1919950 | chr7:143767898 | ARHGEF35 | chr7:143883677-143892736:- | -0.32 | -5.55 | 5.33E-8 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs1919951 | chr7:143768891 | ARHGEF35 | chr7:143883677-143892736:- | -0.33 | -5.88 | 8.91E-9 | Obesity-related traits |
| BLCA | cis | rs1474698 | 1 | rs1925148 | chr6:56095672 | COL21A1 | chr6:55921389-56258892:- | 0.36 | 6.61 | 1.32E-10 | Pulse pressure |
| BLCA | cis | rs1474698 | 1 | rs1925152 | chr6:56102709 | COL21A1 | chr6:55921389-56258892:- | 0.33 | 5.86 | 1.01E-8 | Pulse pressure |
| BLCA | cis | rs1930961 | 1 | rs1930961 | chr22:25875265 | CRYBB2 | chr22:25615612-25627836:+ | 0.95 | 10.44 | 1.24E-22 | Bipolar disorder with mood-incongruent psychosis |
| BLCA | cis | rs1933182 | 1 | rs1933182 | chr1:109999838 | AMIGO1 | chr1:110049447-110052336:- | -0.24 | -3.97 | 8.58E-5 | Chronic kidney disease |
| BLCA | cis | rs6931865 | 1 | rs1935496 | chr6:144068066 | PEX3 | chr6:143771918-143811749:+ | 0.21 | 3.95 | 9.14E-5 | Erectile dysfunction in type 1 diabetes |
| BLCA | cis | rs853679 | 1 | rs1936365 | chr6:28268452 | ZNF389 | chr6:28129551-28137375:+ | 0.31 | 4.04 | 6.45E-5 | Depression |
| BLCA | cis | rs881375 | 1 | rs1953126 | chr9:123640500 | LOC253039 | chr9:123605320-123616644:+ | -0.38 | -6.59 | 1.43E-10 | Rheumatoid arthritis |